Deskrizzjoni
Struttura Kimika: CFI02
Nru CAS: 273735-28-7
CFI02(CFI 02;CFI-02)
Katalgu Nru.: URK-V2341Użat biss għal-laboratorju.
CFI02 (CFI-02) huwa inibitur speċifiku tal-fużjoni medjata mill-glikoproteina B taċ-ċitomegalovirus uman (HCMV) b'IC50 ta' 40 nM kontra r-razza HCMV AD169 adattata fil-laboratorju.
Attività Bijoloġika
CFI02 (CFI-02) is a specific inhibitor of human cytomegalovirus (HCMV) glycoprotein B-mediated fusion with IC50 of 40 nM against laboratory adapted HCMV strain AD169; reduces HCMV yield by >3 logs at 1 uM, and shows no inhibitory activity against closely related betaherpesviruses (including MCMV, simian CMV, and RCMV) (IC50>20 uM) as well as cytotoxic effect (CC50>50 uM).
Proprjetajiet fiżikokimiċi
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M.Wt |
491.43 |
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Formula |
C18H11F6N5OS2 |
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CAS Nru. |
273735-28-7 |
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Ħażna |
Trab solidu -20 grad 3 snin; 4 grad 2 snin |
Fis-Solvent -80 grad 6 Xhur -20 grad 1 Xahar |
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Solubilità |
10 mM f'DMSO |
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Isem Kimiku |
N-(4-(3-(3,5-bis(trifluworomethyl)phenyl)thioureido)phenyl)-1,2,3-thiadiazole{{8} }carboxamide |
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Referenzi
1. Jones TR, et al. J Virol. 2004 Frar;78(3):1289-300.
2. Bloom JD, et al. Bioorg Med Chem Lett. 2003 Settembru 1;13(17):2929-32.
URK-V2341_COAURK-V2341_SDSURK-V2341_TDS
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It-tags Popolari: cfi02 nru tal-kas:273735-28-7
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